Peter G. Stock, M.D., Ph.D.
Professor of Surgery
Surgical Director, Kidney and Pancreas Transplant Program
Surgical Director, Pediatric Renal Transplant Program
Co-Director, Pancreatic Islet Cell Transplant Program
Program, Director, T32 Training Program in Transplant Surgery
Surgical Director, Kidney and Pancreas Transplant Program
Surgical Director, Pediatric Renal Transplant Program
Co-Director, Pancreatic Islet Cell Transplant Program
Program, Director, T32 Training Program in Transplant Surgery
Contact Information
Education
- University of Illinois, Urbana, IL, B.S., Biology, 1974-78
- University of Illinois, Chicago, IL, M.D., Medicine, 1978-82
- University of Minnesota, Minneapolis, MN, Ph.D., Surgery, 1985-92
Residencies
- University of Minnesota, Intern, General Surgery, 1982-83
- University of Minnesota, Resident, General Surgery, 1983-90
Fellowships
- University of California, San Francisco, Fellow, Transplant Surgery, 1990-92
Board Certifications
- American Board of Surgery, 1991
Clinical Expertise
- Bile Duct Injuries
- Bile Duct Strictures
- Cholangiocarcinoma (Bile Duct Cancer)
- Choledochal Cyst Disease
- Dialysis Access
- End-Stage Kidney Disease
- Fulminant Hepatic Failure
- Hepatitis B
- Hepatitis C
- Hepatocellular Carcinoma (Liver Cancer)
- Kidney and LIver Transplantation in HIV Patients
- Kidney Transplantation
- Liver Transplantation
- Living Donor Kidney Transplantation
- Living Donor Liver Transplantation
- Pancreas Transplantation
- Pancreatic Islet Cell Transplantation
- Pediatric Kidney Transplantation
- Pediatric Liver Transplantation
- Polycystic Kidney Disease
- Polycystic Liver Disease
- Portal Hypertension
Research Interests
- Induction of transplantation tolerance to block alloimmunity and recurrent autoimmunity following pancreatic islet transplantation
- Safety and efficacy of solid organ transplantation in people with HIV
Biography
Peter G. Stock, M.D., Ph.D. is Professor of Surgery at UCSF, Surgical Director of the Pediatric Renal Transplantation Program and Surgical Director of the Pancreas Transplant Program. He was trained at the University of Minnesota, completing a surgical residency before coming to UCSF for a transplant fellowship. He joined the UCSF faculty in 1992. Dr. Stock specializes in liver, kidney and pancreas transplantation.
For many years, Dr. Stock was Chair of the Department of Surgery Research Committee. Under his outstanding leadership. he has helped to establish UCSF Surgery as one of the top research programs for surgical residents in the U.S.
A clincial investigation on which Dr. Stock served as principal investigator led the passage of the Hope Act lifting the ban on research for transplanting organs between HIV-positive donors and recipients.
Dr. Stock is a frequent presenter on issues related to transplantation and immunosuppression, and holds membership in numerous professional and honorary societies.
Awards & Honors
Award
Confired By
Date
Research Overview
Pancreatic Islet Transplantation
The translational research in the field of pancreatic islets revolves around clinical trials of the safety and efficacy of islet transplantation in patients with Type I diabetes. The clinical trials are funded by the National Institutes of Health (NIH) and the Juvenile Diabetes Research Foundation (JDRF). These clinical trials focus on novel immunosuppressive strategies that utilize co-stimulatory blockade to prevent the immune response against pancreatic islets with a regimen that is not toxic to kidneys or beta cells.
Related research involves improving the techniques required for isolating pancreatic islets from the pancreas, which is being conducted in a fully compliant GMP laboratory facility. The study of the alloimmune and autoimmune response following islet transplantation will be conducted to determine the efficacy of the immunosuppressive strategies. Further translational studies will include methods of expanding the source of beta cells, using direct proliferation, as well as manipulation of precursor cells localized in the adult pancreas. We are currently funded (PI) for a translational grant from California Institute of Regenerative Medicine (CIRM) to bring embryonic stem cell-derived beta cells to a clinical trial.
Solid Organ Transplantation in People with HIV
With the advent of highly active anti-retroviral therapy (HAART), HIV has been a chronic disease. People with HIV are no longer dying from progression of HIV to AIDS, but rather as a result of end stage live disease (viral hepatitis co-infection) and kidney disease (HIV nephropathy). Our laboratory heads up the large NIH-sponsored national multicenter trial which is studying the safety and efficacy of solid organ transplantation in people with HIV. Translational research is exploring the impact of HIV on organ function and the impact of immunosuppression on the immune response against HIV and associated copathogens.
Research & Funding
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- Filling a Void of Research (FAVOR) Training for Transplant SurgeonsSponsor: NIH/NIAIDSponsor ID: T32AI125222Funding Period:Aug 2016-Jul 2021Principal Investigator
- Impact of CCR5 Blockade in HIV+ Kidney Transplant RecipientsSponsor: NIH/NIAIDSponsor ID: U01AI118594Funding Period:Aug 2015-Jul 2020Principal Investigator
- Diabetes Research CenterSponsor: NIH/NIDDKSponsor ID: P30DK063720Funding Period:Sep 2002-Mar 2020Co-Investigator
- Sofosbuvir and Ledipasvir in HIV/HCV Coinfected Pre and Post Liver TransplantSponsor: NIH/NIAIDSponsor ID: U01AI115714Funding Period:Jan 2015-Dec 2017Principal Investigator
- Solid Organ Transplantation in HIV: Multi-Site StudySponsor: NIH/NIAIDSponsor ID: U01AI052748Funding Period:Aug 2003-Aug 2013Principal Investigator
- General Clinical Research CenterSponsor: NIH/NCRRSponsor ID: M01RR000079Funding Period:Dec 1974-Mar 2009Co-Investigator
Clinical Trials
Data provided by UCSF Profiles, powered by CTSI
- Study ID: NCT03977662Start Date: Jul 2019Estimated Completion Date: Jun 2023Condition(s): Diabetes, Diabetes Type 1
- Study ID: NCT03500315Start Date: Apr 2018Estimated Completion Date: Aug 2022Condition(s): HIV/AIDS, Kidney Transplant
- Study ID: NCT02741323Start Date: Jan 2017Estimated Completion Date: Jul 2022Condition(s): HIV/AIDS, Kidney Disease, Kidney Transplant
- Study ID: NCT02533934Start Date: Aug 2016Estimated Completion Date: Dec 2019Condition(s): HIV/AIDS, Hepatitis C, Cirrhosis, Fibrosis, Liver Transplant
- Study ID: NCT02429869Start Date: Feb 2016Estimated Completion Date: Jan 2018Condition(s): HIV/AIDS, Kidney Transplant, Liver Transplant
- Study ID: NCT01856257Start Date: Jul 2013Estimated Completion Date: Apr 2016Condition(s): Primary Renal Allograft Candidate, Kidney Transplant
- Study ID: NCT01790594Start Date: Feb 2013Estimated Completion Date: Aug 2016Condition(s): Simultaneous Kidney and Pancreas Transplantation, Kidney Transplant
- Study ID: NCT00501709Start Date: Feb 2007Estimated Completion Date: Dec 2016Condition(s): Diabetes, Diabetes Type 1
- Study ID: NCT00074386Start Date: Oct 2003Estimated Completion Date: Aug 2013Condition(s): HIV/AIDS, Kidney Disease, Liver Disease, Liver Transplant
Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 243
Data provided by UCSF Profiles, powered by CTSI
- Amara D, Braun HJ, Shui AM, Sorrentino T, Ramirez JL, Lin J, Liu IH, Mello A, Stock PG, Hiramoto JS. Long-Term Lower Extremity and Cardiovascular Complications after Simultaneous Pancreas-Kidney Transplant. Clin Transplant. 2020 Dec 19; e14195. View in PubMed
- Amara D, Wisel SA, Braun HJ, Collisson EA, Friedlander T, Worner G, Roll GR, Hirose R, Stock PG. Metastatic Donor-derived Malignancies Following Simultaneous Pancreas-kidney Transplant: Three Case Reports and Management Strategies. Transplant Direct. 2021 Jan; 7(1):e636. View in PubMed
- Peters MG, Kottilil S, Terrault N, Amara D, Husson J, Huprikar S, Florman S, Sulkowski MS, Durand CM, Luetkemeyer AF, Rogers R, Grab J, Haydel B, Blumberg E, Dove L, Emond J, Olthoff K, Smith C, Fishbein T, Masur H, Stock PG. Retrospective-Prospective Study of Safety and Efficacy of Sofosbuvir based Direct Acting Antivirals in HIV/HCV Coinfected Participants with Decompensated Liver Disease Pre or Post Liver Transplant. Am J Transplant. 2020 Dec 04. View in PubMed
- Witkowski P, Philipson L, Kaufman DB, Ratner L, Abouljoud MS, Bellin M, Buse J, Kandeel F, Stock P, Mulligan D, Markmann JF, Kozlowski T, Andreoni K, Alejandro R, Baidal D, Hardy MA, Wickrema A, Mirmira RG, Fung J, Becker Y, Josephson MA, Bachul PJ, Pyda JS, Charlton M, Millis JM, Gaglia J, Stratta RJ, Fridell JA, Niederhaus S, Forbes RC, Jayant K, Robertson RP, Odorico J, Levy M, Harland R, Abrams PL, Olaitan OK, Kandaswamy R, Wellen J, Japour AJ, Desai CS, Naziruddin B, Balamurugan AN, Barth RN, Ricordi C. The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The "ISLETS FOR US" Collaborative. Am J Transplant. 2020 Nov 29. View in PubMed
- Brian R, Stock P, Syed S, Hirose K, Reilly L, O'Sullivan P. How COVID-19 inspired surgical residents to rethink educational programs. Am J Surg. 2020 Oct 21. View in PubMed
- View All Publications
Videos
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- Consequences of the New Allocation System for Kidney-Pancreas Transplants
- Interview with Peter Stock MD, PhD - ASTS President 2014-2015
- Transplantation to Cure Diabetes Mellitus: Past, Present, and Future - Update 2019
- Interactive Selection Meeting: Who Gets It And Who Doesn't Get It? - UCSF Kidney Transplant Program Update in Transplantation 2018
In the News
- UCSF News Services - - June 13, 2019Researcher of the Month: Peter Stock, MD, PhD As a pivotal figure in HIV-to-HIV organ transplantation and its legalization through the passage of the HIV Organ Policy Equity (HOPE) Act, transplant surgeon Peter G. Stock, MD., PhD., continues to strive toward breakthroughs in research. While Stock is mostly known for his HIV transplantation work, he has been investigating pancreatic islet transplantation (also known as beta cell replacement) to cure type 1 diabetes since his days as a PhD [...]
- Stem Cellar, The Official Blog of CIRM, California's Stem Cell Agency - - May 23, 2019The California Institute for Regenerative Medicine (CIRM) awarded $11.08 Million to Dr. Peter Stock at the University of California San Francisco (UCSF) to conduct a clinical trial for treatment of Type 1 Diabetes (T1D)... The trial will be using parathyroid glands to aid in the success and viability of the transplant procedure. Co-transplantation of islets and parathyroid glands, from the same donor, substantially increases beta cell survival, potentially enabling adequate long-term [...]
- UCSF Department of Surgery - - March 27, 2018The UCSF Department of Surgery now ranks No. 3 nationally in NIH research funding among all academic surgery programs, a stunning rise from 6th the last time the survey was done. Three Department of Surgery faculty also ranked in the top 20 of all NIH-funded principal investigators nationally in the category of surgery. The highly respected Blue Ridge Institute for Medical Research utilized data from the Research Portfolio Online Reporting Tool (RePORT) to survey U.S. medical schools for their [...]
- UCSF Department of Surgery - - March 12, 2018Transplant surgeons Sandy Feng, M.D., Ph.D. and Peter G. Stock, M.D., Ph.D. continued their stellar records of accomplishment in garnering NIH funding for their cutting-edge clinical research, ranking in the top 20 of all NIH-Funded principal investigators in the category of surgery nationally for 2017. Stock ranked 8th and Feng 20th out of 534 investigators nationwide, both in the top 4%, this according to survey data analyzed by the highly respected Blue Ridge Institute for Medical Research. [...]
- UCSF Transplant Surgery - - June 26, 2017President Barack Obama signs the HOPE Act legislation in November 2013. Peter Stock (far left) had earlier testified before Congress in support of the legislation, which overturned a federal ban on HIV-to-HIV transplants. Photo by Evan Vucci UCSF News reports on the epic battle, led by UCSF transplant surgeon Peter G. Stock, M.D., Ph.D., to repeal long-standing federal and state laws banning HIV-to-HIV organ transplantation, this after having served as lead Principal Investigator on [...]
- UCSF Department of Surgery - - January 06, 2017The NIH has awarded the UCSF Department of Surgery a T32 training grant, "Filling a Void of Research Training for Transplant Surgeons" (FAVOR). The grant, awarded in August 2016, provides annual funding in the amount of $156,602 for in-depth training of three general surgery residents with an interest in transplant surgery during their two research years, the training to be focused on translational immunology. The program is led by Professors Peter G. Stock, M.D., Ph.D. and Minnie M. Sarwal [...]
- UCSF Transplant Surgery - April 01, 2014"Researchers studying the effects of immune suppressant drugs on transplant patients with HIV have made a surprising discovery: A drug intended to hobble the body's defense system may actually help destroy dormant reservoirs of the virus that causes AIDS In a paper published this week in the American Journal of Transplantation, authors found that when a small group of transplant patients received the drug sirolimus, they experienced a two- to threefold drop in HIV levels, whereas patients who [...]
- UCSF Transplant Surgery - December 05, 2013President Barack Obama signs S. 330: HIV Organ Policy Equity Act during a signing ceremony in the Oval Office, Nov. 21, 2013. (Official White House Photo by Lawrence Jackson) MSNBC reports on President Obama's signing of a bill that ended a decades-old policy that banned organ donations from one HIV-positive person to another. A clinical trial led by UCSF transplant surgeon Peter G. Stock, M.D., Ph.D. was instrumental to the passage of the Hope Act that lifted the ban. The HIV Organ [...]
- UCSF Transplant Surgery - November 14, 2013UCSF News, reporting on the 14th World Congress of the International Pancreas and Islet Transplant Association (IPITA), highlighed improving results in islet cell transplantation: For the worst cases of type 1 diabetes, islet transplantation already has freed hundreds of people from complete dependence on insulin and from life-threatening consequences of the disease. "However, the procedure still is regarded as experimental by the U.S. Food and Drug Administration (FDA). Islets are [...]
- UCSF Transplant Surgery - June 05, 2013"The sun wasn't up at 5 o'clock Wednesday morning, but a new day had already dawned for Matthew Ouimet. Matthew, a 2-year-old Antioch boy who had waited 15 months for a life-sustaining kidney and liver transplant, had his new organs. Dr. John Roberts took the lead on the liver transplant, and Dr. Peter Stock, who handled the kidney procedure in a 12-hour surgery that began around 6 p.m. Tuesday, delivered the good news to parents Kristi and Kelly Ouimet and a half-dozen family members who spent [...]
- UCSF Transplant Surgery - April 11, 2011Last year, a team led by Dr. Peter Stock of UCSF reported on results from a large multicenter study testing the safety and feasibility of transplanting kidneys where both the donor and recipients were infected with HIV, the virus that causes AIDS. The results, reported in the New England Journal of Medicine, showed that the recipients survived nearly as long as non-HIV infected recipients of kidney transplants. As a result of the Stock-led trial, and a just-published paper from Johns Hopkins [...]
- UCSF Transplant Surgery - March 23, 2011"Previously, Uruguay had tried to go it alone, but high mortality rates soon caused doctors to shut the program down. After their initial visit, the UCSF transplant team, including anesthesiologist Claus U. Niemann, MD (pictured first), and surgeons Ryutaro Hirose, MD (pictured second), and Peter Stock, MD, PhD, (pictured third) continued to consult with the team in Uruguay, guiding them through everything from patient selection procedures to the use of immunosuppressive medications [...]
- UCSF Transplant Surgery - November 18, 2010"People infected with the AIDS virus can safely receive a kidney transplant, researchers reported on Wednesday. The finding, published in Thursday's New England Journal of Medicine, is good news for people with HIV who are more prone to kidney disease, in part because of the drugs they must take to stay healthy. Before drug cocktails turned HIV from a death sentence to a chronic condition, patients were not eligible to receive a kidney. But now they can. 'Patient and graft survival are really [...]
- UCSF Transplant Surgery - February 01, 2005"The body's rejection of transplanted organs and tissues is an unfortunate risk of transplant surgery. Historically, rejection rates in a simultaneous pancreas-kidney (SPK) transplant have been as high as 80% and, in 2001, averaged nearly 20%. ........Diabetes Center surgeons Peter Stock, (left) and Chris Freise (right) have been pioneering new methods of immunosuppression for SPK transplants that do not rely upon steroids, with great success...... " Read Full Diabetes Center [...]
